Pseudo 3D RVE BasedFinite Element Simulation on White Matter

题目：Pseudo 3D RVE BasedFinite Element Simulation on White Matter
报告人：潘艺，新泽西州立大学
时间：2014年2月28日（周五）上午10点
地点：力学一楼二楼227会议室
报告人简介
  Dr. Yi Pan is a Postdoctoral Fellow at Rutgers, the State University of New Jersey.He received his Ph.D. degree in Solid Mechanics from Rutgers University in 2010. He received Master of Science in 2003 and Bachelor of Science in 1998,both from University of Science and Technology of China.  He has been working on a couple of research topics including finite element modeling on axon kinematics for brain tissue white matter, micromechanical characterization of nanofiber reinforced composite materials,  damage model for random chopped fiber composites, deign of high thermal conductivity heat spreader for chip packaging. Dr. Pan’s research interests include finite element analysis, micromechanical characterization and damage modeling of advanced composite materials, mechanical behaviors of soft biological tissues, thermal-mechanical design of electronic packaging.

报告摘要
　  Axonal injury represents a critical target for traumatic brain and spinal cord injuries prevention and treatment. Finite element head models are often used to predict brain injury caused by mechanical loading exerted on the head. Many studies have been attempted to understand injury mechanisms and to define mechanical parameters of axonal injury. Mechanical strain has been identified as the proximal cause of axonal injury. Since the microstructure of the brain white matter is locally oriented, the stress and strain fields are highly axon orientation dependent. The accuracy of the finite element simulations depends not only on accurate determination of the material properties but also on precise depiction of the tissues’microstructure (microscopic level). We applied a finite element method and a mircomechanics approach to simulate the kinematics of axon, which was developed according to experimental data, and found that the degree of coupling between the axons and surrounding cells within the tissue will affect the behavior of the tissue. In this study, the finite element model and the kinematic axonal model are applied to the Representative Volume Element (RVE) of central nervous system (CNS) white matter to investigate the tissue level mechanical behavior. The uniaxial tensile test on the white matter tissue will be presented as an example using the RVE.
　 An inverse FE procedure was also developed to identify material parameters of spinal cord white matter by combining the results of uniaxial testing with FE modeling. The combination of experimental testing and FE analysis provides a useful analysis tool for soft biological tissues in general, and specifically enables evaluations of the axonal response to tissue-level loading and subsequent predictions of axonal damage.
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